其他
Cell子刊:微生物-肠-脑轴前景令人兴奋,但如何突破研究瓶颈?
微生物-肠-脑轴
微生物对短链脂肪酸的调控作用
微生物对神经递质的调控作用
未知的微生物产物和神经系统
微生物与神经疾病药物的相互作用
令人兴奋的前景
1.Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van derVeeken, J., deRoos, P., Liu, H., Cross, J.R., Pfeffer, K., Coffer, P.J., andRudensky, A.Y. (2013). Metabolites produced by commensal bacteria promoteperipheral regulatory T-cell gener- ation. Nature 504, 451–455.2.Bellono, N.W., Bayrer, J.R., Leitch, D.B., Castro, J.,Zhang, C., O’Donnell, T.A., Brierley, S.M., Ingraham, H.A., and Julius, D.(2017). Enterochromaffin cells are gut chemosensors that couple to sensoryneural pathways. Cell 170, 185– 198.e16.3.Bjursell, M.K., Martens, E.C., and Gordon, J.I. (2006).Functional genomic and metabolic studies of the adaptations of a prominentadult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period.J. Biol. Chem. 281, 36269–36279.4.Boho ́ rquez, D.V., Shahid, R.A., Erdmann, A., Kreger,A.M., Wang, Y., Calakos, N., Wang, F., and Liddle, R.A. (2015). Neuroepithelialcircuit formed by inner- vation of sensory enteroendocrine cells. J. Clin.Invest. 125, 782–786.5.Bravo, J.A., Forsythe, P., Chew, M.V., Escaravage, E.,Savignac, H.M., Dinan, T.G., Bienenstock, J., and Cryan, J.F. (2011). Ingestionof Lactobacillus strain regulates emotional behavior and central GABAreceptor expression in a mouse via the vagus nerve. Proc. Natl. Acad. Sci. USA 108,16050–16055.6.Byrne, C.S., Chambers, E.S., Morrison, D.J., and Frost,G. (2015). The role of short chain fatty acids in appetite regulation andenergy homeostasis. Int. J. Obes. 39, 1331–1338.7.Chambers, E.S., Viardot, A., Psichas, A., Morrison, D.J.,Murphy, K.G., Zac- Varghese, S.E., MacDougall, K., Preston, T., Tedford, C.,Finlayson, G.S., et al. (2015). Effects of targeted delivery of propionate tothe human colon on appetite regulation, body weight maintenance and adiposityin overweight adults. Gut 64, 1744–1754.8.Chen, H., Nwe, P.K., Yang, Y., Rosen, C.E., Bielecka,A.A., Kuchroo, M., Cline, G.W., Kruse, A.C., Ring, A.M., Crawford, J.M., et al.(2019). A forward chemical genetic screen reveals gut microbiota metabolitesthat modulate host physi- ology. Cell 177, 1217–1231.e18.Clarke, M.B., Hughes, D.T., Zhu, C., Boedeker, E.C., andSperandio, V. (2006). The QseC sensor kinase: a bacterial adrenergic receptor.Proc. Natl. Acad. Sci. USA 103, 10420–10425.9.Cohen, L.J., Kang, H.S., Chu, J., Huang, Y.H., Gordon,E.A., Reddy, B.V., Ter- nei, M.A., Craig, J.W., and Brady, S.F. (2015).Functional metagenomic discov- ery of bacterial effectors in the humanmicrobiome and isolation of commen- damide, a GPCR G2A/132 agonist. Proc. Natl.Acad. Sci. USA 112, E4825–E4834.10.Cohen, L.J., Esterhazy, D., Kim, S.H., Lemetre, C.,Aguilar, R.R., Gordon, E.A., Pickard, A.J., Cross, J.R., Emiliano, A.B., Han,S.M., et al. (2017). Commensal bacteria make GPCR ligands that mimic humansignalling molecules. Nature 549, 48–53.11.Colosimo, D.A., Kohn, J.A., Luo, P.M., Piscotta, F.J.,Han, S.M., Pickard, A.J., Rao, A., Cross, J.R., Cohen, L.J., and Brady, S.F.(2019). Mapping interactions of microbial metabolites with humanG-protein-coupled receptors. Cell Host Microbe 26, 273–282.e7.12.De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D.,Vinera, J., Zitoun, C., Duchampt, A., Ba€ckhed, F., and Mithieux, G. (2014).Microbiota-generated metabolites promote metabolic benefits via gut-brainneural circuits. Cell 156, 84–96.13.Donaldson, G.P., Lee, S.M., and Mazmanian, S.K. (2016).Gut biogeography of the bacterial microbiota. Nat. Rev. Microbiol. 14,20–32.14.Egerod, K.L., Petersen, N., Timshel, P.N., Rekling, J.C.,Wang, Y., Liu, Q., Schwartz, T.W., and Gautron, L. (2018). Profiling of Gprotein-coupled recep- tors in vagal afferents reveals novel gut-to-brainsensing mechanisms. Mol. Metab. 12, 62–75.15.Erny, D., Hrabe de Angelis, A.L., and Prinz, M. (2017).Communicating systems in the body: how microbiota and microglia cooperate.Immunology 150, 7–15.16.Frost, G., Sleeth, M.L., Sahuri-Arisoylu, M., Lizarbe,B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang,S., et al. (2014). The short- chain fatty acid acetate reduces appetite via acentral homeostatic mecha- nism. Nat. Commun. 5, 3611.17.Fung, T.C., Vuong, H.E., Luna, C.D.G., Pronovost, G.N.,Aleksandrova, A.A., Riley, N.G., Vavilina, A., McGinn, J., Rendon, T., Forrest,L.R., and Hsiao, E.Y. (2019). Intestinal serotonin and fluoxetine exposuremodulate bacterial colonization in the gut. Nat. Microbiol. 4,2064–2073.18.Furusawa, Y., Obata, Y., Fukuda, S., Endo, T.A., Nakato,G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al.(2013). Commensal microbe-derived butyrate induces the differentiation ofcolonic regulatory T cells. Nature 504, 446–450.19.Gustafsson, B. (1946-1947). Germ-free rearing of rats.Acta Anat. (Basel) 2, 376–391.20.Hockley, J.R.F., Taylor, T.S., Callejo, G., Wilbrey,A.L., Gutteridge, A., Bach, K., Winchester, W.J., Bulmer, D.C., McMurray, G.,and Smith, E.S.J. (2019). Single-cell RNAseq reveals seven classes of colonicsensory neuron. Gut 68, 633–644.21.Høverstad, T., and Midtvedt, T. (1986). Short-chain fattyacids in germfree mice and rats. J. Nutr. 116, 1772–1776.22.Hsu, B.B., Gibson, T.E., Yeliseyev, V., Liu, Q., Lyon,L., Bry, L., Silver, P.A., and Gerber, G.K. (2019). Dynamic modulation of thegut microbiota and metabo- lome by bacteriophages in a mouse model. Cell HostMicrobe 25, 803–814.e5.23.Jackson, M.A., Verdi, S., Maxan, M.E., Shin, C.M.,Zierer, J., Bowyer, R.C.E., Martin, T., Williams, F.M.K., Menni, C., Bell,J.T., et al. (2018). Gut microbiota associations with common diseases andprescription medications in a popu- lation-based cohort. Nat. Commun. 9,2655.24.Kashem, S.W., Riedl, M.S., Yao, C., Honda, C.N.,Vulchanova, L., and Kaplan, D.H. (2015). Nociceptive sensory fibers driveinterleukin-23 production from CD301b+ dermal dendritic cells and driveprotective cutaneous immunity. Im- munity 43, 515–526.25.Kupari, J., Ha€ring, M., Agirre, E., Castelo-Branco, G., andErnfors, P. (2019). An atlas of vagal sensory neurons and their molecularspecialization. Cell Rep. 27, 2508–2523.e4.26.Larraufie, P., Martin-Gallausiaux, C., Lapaque, N., Dore,J., Gribble, F.M., Re- imann, F., and Blottiere, H.M. (2018). SCFAs stronglystimulate PYY produc- tion in human enteroendocrine cells. Sci. Rep. 8,74.27.Leulier, F., MacNeil, L.T., Lee, W.J., Rawls, J.F., Cani,P.D., Schwarzer, M., Zhao, L., and Simpson, S.J. (2017). Integrativephysiology: at the crossroads of nutrition, microbiota, animal physiology, andhuman health. Cell Metab. 25, 522–534.28.Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow,A., Anderson, E.E., Bro- chado, A.R., Fernandez, K.C., Dose, H., Mori, H., etal. (2018). Extensive impact of non-antibiotic drugs on human gut bacteria.Nature 555, 623–628.29.Maini Rekdal, V., Bess, E.N., Bisanz, J.E., Turnbaugh,P.J., and Balskus, E.P. (2019). Discovery and inhibition of an interspecies gutbacterial pathway for Levodopa metabolism. Science 364, eaau6323.30.Mertens, K.L., Kalsbeek, A., Soeters, M.R., and Eggink,H.M. (2017). Bile acid signaling pathways from the enterohepatic circulation tothe central nervous system. Front. Neurosci. 11, 617.31.Milshteyn, A., Colosimo, D.A., and Brady, S.F. (2018).Accessing bioactive nat- ural products from the human microbiome. Cell HostMicrobe 23, 725–736.32.Ridaura, V.K., Faith, J.J., Rey, F.E., Cheng, J., Duncan,A.E., Kau, A.L., Griffin, N.W., Lombard, V., Henrissat, B., Bain, J.R., et al.(2013). Gut microbiota from twins discordant for obesity modulate metabolism inmice. Science 341, 1241214.33.Sgritta, M., Dooling, S.W., Buffington, S.A., Momin,E.N., Francis, M.B., Brit- ton, R.A., and Costa-Mattioli, M. (2019). Mechanismsunderlying microbial- mediated changes in social behavior in mouse models ofautism spectrum dis- order. Neuron 101, 246–259.e6.34.Smith, P.M., Howitt, M.R., Panikov, N., Michaud, M.,Gallini, C.A., Bohlooly-Y, M., Glickman, J.N., and Garrett, W.S. (2013). Themicrobial metabolites, short- chain fatty acids, regulate colonic Treg cellhomeostasis. Science 341, 569–573.35.Strandwitz, P. (2018). Neurotransmitter modulation by thegut microbiota. Brain Res. 1693 (Pt B), 128–133.36.Strandwitz, P., Kim, K.H., Terekhova, D., Liu, J.K.,Sharma, A., Levering, J., McDonald, D., Dietrich, D., Ramadhar, T.R., Lekbua,A., et al. (2019). GABA- modulating bacteria of the human gut microbiota. Nat.Microbiol. 4, 396–403.37.Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V.,Mardis, E.R., and Gordon, J.I. (2006). An obesity-associated gut microbiomewith increased ca- pacity for energy harvest. Nature 444, 1027–1031.Valenstein, E.S. (2002). The discovery of chemicalneurotransmitters. Brain Cogn. 49, 73–95.38.Vuong, H.E., Yano, J.M., Fung, T.C., and Hsiao, E.Y.(2017). The microbiome and host behavior. Annu. Rev. Neurosci. 40,21–49.39.Wallace, B.D., Wang, H., Lane, K.T., Scott, J.E., Orans,J., Koo, J.S., Venka- tesh, M., Jobin, C., Yeh, L.A., Mani, S., and Redinbo,M.R. (2010). Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.Science 330, 831–835.40.Yano, J.M., Yu, K., Donaldson, G.P., Shastri, G.G., Ann,P., Ma, L., Nagler, C.R., Ismagilov, R.F., Mazmanian, S.K., and Hsiao, E.Y.(2015). Indigenous bacteria from the gut microbiota regulate host serotoninbiosynthesis. Cell 161, 264–276.41.Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R.,and Goodman, A.L. (2019a). Mapping human microbiome drug metabolism by gutbacteria and their genes. Nature 570, 462–467.42.Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R.,and Goodman, A.L. (2019b). Separating host and microbiome contributions to drugpharmacokinetics and toxicity. Science 363, eaat9931.