益生菌含片会成为下一个口腔护理明星产品吗?
益生菌或可缓解老年人的念珠菌相关性义齿性口炎
Australian Dental Journal[IF:1.282]
① 选取36名患有不同程度的义齿性口炎(DS)的老人,摄入含或不含鼠李糖乳杆菌SP1的牛奶,对比两组的DS患病率、严重程度和念珠菌数量;② 两组的DS患病率均有下降,但只有益生菌组的受试者在整个试验过程中,DS的严重程度和念珠菌数均显著降低;③ 口腔/修复卫生教育指导与受试者的DS患病率相关;④ 食用鼠李糖乳杆菌SP1和制定口腔/修复卫生方案可缓解老年人DS的疾病严重程度。
Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1
04-08, doi: 10.1111/adj.12692
【主编评语】Australian Dental Journal上发表的一项最新研究,发现摄入含有鼠李糖乳杆菌SP1的牛奶,可缓解老年人义齿性口炎的严重程度。(@szx)
JPR:罗伊氏乳杆菌或可改善牙种植体术后炎症
Journal of Periodontal Research[IF:2.613]
① 接受口腔种植体手术后患有黏膜炎(22人)或牙种植体周围炎(22人)的患者随机分成益生菌(罗伊氏乳杆菌)组和安慰剂对照组,干预30天;② 相比于单独的机械清理,益生菌可改善口腔检查出血情况和牙周袋深度水平;③ 但对种植体周围的菌群影响非常有限,仅在黏膜炎患者中发现人牙龈卟啉单胞菌的细菌负荷显著降低;④ 连续服用罗伊氏乳杆菌30天,再配合机械清理护理至少90天,可改善黏膜炎和牙种植体周围炎的临床参数。
Clinical and microbiological evaluation of the effect of Lactobacillus reuteri in the treatment of mucositis and peri-implantitis: A triple-blind randomized clinical trial
2018-01-19, doi: 10.1111/jre.12523
【主编评语】这是近期发表的一项小规模初步临床试验,发现服用罗伊氏乳杆菌配合机械清理,可在一定程度上改善口腔种植体手术引发的相关炎症,推荐专业人士参考。(@szx)
FM:促进口腔健康并来自于口腔的潜在益生菌
Frontiers in Microbiology[IF:4.259]
① 一些细菌菌株作为口腔益生菌的潜能正在被测试,但这些细菌被分离出的生态位通常并非其发挥益生菌功能的地点,特别是那些分离自粪便样品的细菌;② 与口腔健康相关的口腔生态位中的菌群可能比肠道益生菌有着更好的促进口腔健康的作用;③ 在口腔中定殖的细菌中,链球菌dentisani是一种分离自无龋齿健康者的牙菌斑中的新链球菌属菌种;④ 从98%的健康人牙菌斑样品中可分离出链球菌dentisani,后者不会产生任何毒性二级代谢产物。
Health-Associated Niche Inhabitants as Oral Probiotics: The Case of Streptococcus dentisani
2017-03-10, doi: 10.3389/fmicb.2017.00379
【主编评语】难得的关于口腔来源益生菌的研究,强烈推荐。(@蓝灿辉 | 热心肠先生)
AMB:益生菌预防龋齿的机制与应用(综述)
Applied Microbiology and Biotechnology[IF:3.67]
① 致龋齿性口腔细菌形成的生物膜与饮食中的碳水化合物的复杂互作可诱发龋齿;② 龋齿的致病因素包括:产酸细菌(变异链球菌、表兄链球菌等)、低于正常的唾液流及功能、食用过多的可发酵碳水化合物;③ 龋齿的保护因素包括:唾液流及其组分、氟化物、抗菌物质;④ 副干酪乳杆菌中的某些菌株已被证实具有口腔益生及抗龋齿作用;⑤ 益生菌促进口腔健康的机制包括:与致病菌竞争粘附空间、养分,产生抗菌化合物,增强宿主免疫反应等。
The implication of probiotics in the prevention of dental caries
2017-11-30, doi: 10.1007/s00253-017-8664-z
【主编评语】这是Applied Microbiology and Biotechnology[IF:3.420]发表的系统性总结口腔益生菌的一篇综述,相关领域研究不少,但质量参差不齐,本综述供参考阅读。(@szx)
JP:特定双歧杆菌或能促进牙龈健康
Journal of Periodontology[IF:2.768]
① 51受试者随机分成安慰剂组和动物双歧杆菌乳双歧亚种DN-173010组;② 通过补充含或不含益生菌的酸奶28天,随后5天不进行任何口腔卫生处理,处理前后组间无差异;③ 在牙菌斑聚集后,与对照组相比,益生菌组中所有参数显著改善:牙菌斑和牙龈炎分数较低,牙周探诊出血较少,龈沟液体积增加较少,总白介素-1β的数量/浓度比值较低;④ 在不进行口腔卫生清洁的情况下,使用益生菌酸奶补充动物双歧杆菌,对牙菌斑积累和牙龈炎症参数有积极作用。
The Influence of a Bifidobacterium Animalis Probiotic on Gingival Health: a Randomized Controlled Clinical Trial
2017-07-28, doi: 10.1902/jop.2017.170213
【主编评语】这是一项纳入样本数不多,但有一定说服力的RCT研究,发现摄入动物双歧杆菌乳双歧亚种DN-173010株,或能改善牙菌斑的状态,促进牙龈健康。值得看一看,特别推荐。(@szx)
唾液乳杆菌抑制变异链球菌及白色念珠菌形成的致龋齿生物膜
Nutrients[IF:4.171]
① 选取59名患有早期龋齿的儿童,分为初始牙釉质脱矿和牙本质损伤两组;② 分别从牙菌斑中分离出变异链球菌和白色念珠菌,分析唾液乳杆菌对其形成双菌种生物膜能力的影响;③ 变异链球菌可增加白色念珠菌的克隆数及双菌种生物膜的生物量,并促进白色念珠菌 菌丝形成;④ 唾液乳杆菌抑制了可促进龋齿发生的双菌种生物膜的形成,降低生物膜生物量,并降低细菌和真菌数量;⑤ 同时,益生菌抑制白色念珠菌菌丝和芽管的形成,降低其致病性。
Effect of a Lactobacillus Salivarius Probiotic on a Double-Species Streptococcus Mutans and Candida Albicans Caries Biofilm
2017-11-14, doi: 10.3390/nu9111242
【主编评语】Nutrients上发表的一项最新研究,在59名龋齿儿童的口腔中分离出变异链球菌和白色念珠菌,发现唾液乳杆菌可抑制两个菌种形成的致龋齿生物膜。(@szx)
(滑动下方文字查看)
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参考文章
https://www.nzherald.co.nz/sponsored-stories/news/article.cfm?c_id=1503708&objectid=12289303
https://www.nutraingredients.com/News/Promotional-Features/DuPont-Moving-probiotics-beyond-the-gut-to-improve-oral-health
编辑:崔心伟